Mizacorat

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Chemical Structure| 1893415-00-3 同义名 : AZD9567
CAS号 : 1893415-00-3
货号 : A1177085
分子式 : C27H28F2N4O3
纯度 : 99%+
分子量 : 494.533
MDL号 : MFCD31619227
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(212.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mizacorat is a potent, orally active, non-steroidal and selective glucocorticoid receptor modulator (SGRM) with an IC50 of 3.8 nM. It has demonstrated superior efficacy in a streptococcal cell wall (SCW) reactivation model of joint inflammation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.11mL

2.02mL

1.01mL

20.22mL

4.04mL

2.02mL
参考文献

[1]Ripa L, et al. Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile. J Med Chem. 2018 Mar 8;61(5):1785-1799.