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MARK4 inhibitor 1

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Chemical Structure| 2271081-58-2 同义名 : -
CAS号 : 2271081-58-2
货号 : A1177000
分子式 : C20H18N6O3
纯度 : 98%
分子量 : 390.395
MDL号 : MFCD32693877
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 4 mg/mL(10.25 mM),配合低频超声,并调节pH至2,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 MARK4 inhibitor 1 is a potent and selective MARK4 inhibitor with an IC50 value of 1.54 μM. MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis[1].In the concentration range of less than 200 µM for 24-48 hours, MARK4 inhibitor 1 inhibited cell proliferation and cell migration in a concentration-dependent manner, including MCF-7, MDA-MB-435s and HepG2 cells, with IC50 values of 6.22 μM, 9.94 μM and 8.14 μM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.81mL

2.56mL

1.28mL

25.62mL

5.12mL

2.56mL

参考文献

[1]Aneja B, et al. Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. Eur J Med Chem. 2019 Feb 1;163:840-852.