DLinDMA

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Chemical Structure| 871258-12-7 同义名 : 1,2-Dilinoleyloxy-N,N-dimethyl-3-aminopropane
CAS号 : 871258-12-7
货号 : A1176911
分子式 : C41H77NO2
纯度 : 99%+
分子量 : 616.056
MDL号 : MFCD31715447
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(170.44 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(162.32 mM),注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇

动物实验配方:
生物活性
描述 DLinDMA is an ionisable cationic lipid that is the main lipid component of Stable Nucleic Acid Lipid Particles (SNALPs) and a benchmark lipid. The structure of DLinDMA can be divided into three main regions: the hydrocarbon chain, the linker, and the headgroup, and it can be used for siRNA delivery[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.62mL

0.32mL

0.16mL

8.12mL

1.62mL

0.81mL

16.23mL

3.25mL

1.62mL

参考文献

[1]Semple SC, et al. Rational design of cationic lipids for siRNA delivery. Nat Biotechnol. 2010 Feb;28(2):172-6.