产品说明书
O-304
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同义名 : | O-304X |
| CAS号 : | 1261289-04-6 | |
| 货号 : | A1176833 | |
| 分子式 : | C16H11Cl2N3O2S | |
| 纯度 : | 99%+ | |
| 分子量 : | 380.248 | |
| MDL号 : | MFCD31657425 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 30 mg/mL(78.9 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is activated in response to an energy shortage. When pathological conditions cause ATP levels to fall, AMPK is activated to restore cellular energy homeostasis[1]. O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. It exhibits a great potential as a drug to treat type 2 diabetes (T2D) and associated cardiovascular complications. Mice fed with a high-fat diet (HFD), denoted DIO mice, were treated by oral gavage with vehicle, O304, Metformin, or O304+Metformin (100 mg/kg/day) each for 8 weeks. O304 and O304+Metformin, but not Metformin, averted the HFD-provoked increase in fasted glucose and plasma insulin levels and inhibited insulin resistance[2]. Postoperative pain mice models made by incision in the left plantar hindpaw were treated by oral gavage with vehicle, metformin 200 mg/kg, O304 200 mg/kg and O304 200 mg/kg plus metformin 200 mg/kg, for 3 days. O304 or metformin increased von Frey thresholds (reduced mechanical hypersensitivity) in plantar incision mice compared to vehicle-treated incision mice[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.63mL 0.53mL 0.26mL |
13.15mL 2.63mL 1.31mL |
26.30mL 5.26mL 2.63mL |
| 参考文献 |
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