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eCF506

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Chemical Structure| 1914078-41-3 同义名 : -
CAS号 : 1914078-41-3
货号 : A1176814
分子式 : C26H38N8O3
纯度 : 99%+
分子量 : 510.632
MDL号 : MFCD31657410
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(117.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 eCF506 is a potent, orally active inhibitor of the non-receptor tyrosine kinase Src, with an IC50 value of <0.5 nM. eCF506 inhibits the phosphorylation of SRC and FAK at low nanomolar levels, with complete inhibition of phosphorylation at 100 nM. eCF506 inhibits only SFK, with sub-nanomolar IC50 values for SRC and YES (IC50=0.5, 2.1 nM). It is noted that eCF506 shows a large difference in activity between ABL and its primary target, SRC (>950-fold difference)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.96mL

0.39mL

0.20mL

9.79mL

1.96mL

0.98mL

19.58mL

3.92mL

1.96mL
参考文献

[1]Fraser C, et al. Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. J Med Chem. 2016 May 26;59(10):4697-710.