产品说明书

Elexacaftor

Print
Chemical Structure| 2216712-66-0 同义名 : VX-445
CAS号 : 2216712-66-0
货号 : A1176769
分子式 : C26H34F3N7O4S
纯度 : 99%+
分子量 : 597.653
MDL号 : MFCD32067875
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(200.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Elexacaftor is a modulator of CFT that promotes CFTR processing and trafficking, thereby increasing the amount of CFTR on the cell surface[1].Elexacaftor is a new generation CFTR modifier designed to restore the function of the Phe508del CFTR protein. Elexacaftor has potential for the treatment of cystic fibrosis[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.37mL

1.67mL

0.84mL

16.73mL

3.35mL

1.67mL
参考文献

[1]Alexander Russell Abela, et al. MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR , PHARMACEUTICAL COMPOSITIONS , METHODS OF TREATMENT , AND PROCESS FOR MAKING THE MODULATOR. US 20180162839 A1.

[2]Keating D, et al. VX-445-Tezacaftor-VX-770 in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. N Engl J Med. 2018 Oct 25;379(17):1612-1620.