产品说明书
Synta66
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同义名 : | - |
| CAS号 : | 835904-51-3 | |
| 货号 : | A1176693 | |
| 分子式 : | C20H17FN2O3 | |
| 纯度 : | 99% | |
| 分子量 : | 352.359 | |
| MDL号 : | MFCD30719243 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 80 mg/mL(227.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Synta66 is an inhibitor of Orai. At a concentration of 10 μM, Synta66 attenuates the SOCE peak of Müller's glia[1].At 10 μM, Synta66 almost completely blocks Ca2+ entry signals induced by CaCl2 addition, and in platelets moderately reduces Ca2+ mobilisation from stores by 10%-30%. Synta66 inhibits plasma human platelet activation and whole blood thrombosis. Synta66 also inhibits platelet reactions and thrombosis in mice[2].Synta66 (10 μM) inhibited the LAD2 human mast cell line, significantly inhibited FcεRI-stimulated histamine and TNFα secretion, and differentially affected FcεRI-stimulated prostaglandin D2 and cytokine release[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.84mL 0.57mL 0.28mL |
14.19mL 2.84mL 1.42mL |
28.38mL 5.68mL 2.84mL |
| 参考文献 |
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