UCL 2077

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Chemical Structure| 918311-87-2 同义名 : -
CAS号 : 918311-87-2
货号 : A1176635
分子式 : C25H22N2
纯度 : 96%
分子量 : 350.456
MDL号 : MFCD00585879
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(342.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 UCL 2077 is a selective sAHP channel blocker (IC50 value of 500 nM in hippocampal neurons in culture) with minimal effects on Ca2+ channels, action potentials, input resistance, the medium after hyperpolarization[1].UCL 2077 is also a subtype-selective blocker of epilepsy-associated KCNQ channels[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.85mL

0.57mL

0.29mL

14.27mL

2.85mL

1.43mL

28.53mL

5.71mL

2.85mL
参考文献

[1]Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502.

[2]Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.