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A 1120

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Chemical Structure| 1152782-19-8 同义名 : -
CAS号 : 1152782-19-8
货号 : A1176615
分子式 : C20H19F3N2O3
纯度 : 99%+
分子量 : 392.372
MDL号 : MFCD12912393
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(267.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Retinol-binding protein 4 (RBP4) is a serum protein that transports retinol from the liver to other tissues. A1120 is a high affinity, non-retinoid ligand for RBP4 with a Ki value of 8.3nM. The IC50 values of A1120 for human RBP4 and mouse RBP4 are 90nM and 66nM, respectively. In B6D2F1 mice, a hybrid F1 strain between C57Bl/6 and DBA/2, single oral administration of 30mg/kg A1120 decreased serum levels of RBP4 and retinol with the peak reduction observed at 12 hours after treatment. In B6D2F1 mice fed a high-fat diet for 6 weeks, administration of A1120 (as a diet admixture at 30mg/kg) for additional 4 – 6 weeks did not affect glucose levels following the oral glucose challenge[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.74mL

2.55mL

1.27mL

25.49mL

5.10mL

2.55mL
参考文献

[1]Motani A, Wang Z, Conn M, Siegler K, Zhang Y, Liu Q, Johnstone S, Xu H, Thibault S, Wang Y, Fan P, Connors R, Le H, Xu G, Walker N, Shan B, Coward P. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009 Mar 20;284(12):7673-80.