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YM17E

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Chemical Structure| 124900-72-7 同义名 : -
CAS号 : 124900-72-7
货号 : A1176487
分子式 : C40H56N6O2
纯度 : 98%+
分子量 : 652.912
MDL号 : -
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(183.79 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 YM17E is equally effective in inhibiting ACAT activity in the liver as it is in the intestines, with IC50 values of 45 and 34 nM, respectively[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.53mL

0.31mL

0.15mL

7.66mL

1.53mL

0.77mL

15.32mL

3.06mL

1.53mL
参考文献

[1]Uchida T, et al. Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats. Atherosclerosis. 1998 Mar;137(1):97-106.

[2]Kashiwa M, et al. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs. Jpn J Pharmacol. 1997 Jan;73(1):41-50.