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ZINC13466751

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Chemical Structure| 117953-17-0 同义名 : -
CAS号 : 117953-17-0
货号 : A1176416
分子式 : C20H21N5O2
纯度 : 99%+
分子量 : 363.413
MDL号 : N/A
存储条件:

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(137.58 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 ZINC13466751 effectively inhibits the interaction between HIF-1α and VHL, demonstrating an IC50 value of 2.0 µM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.28mL

13.76mL

2.75mL

1.38mL

27.52mL

5.50mL

2.75mL

参考文献

[1]Xue X, et al. Discovery of novel inhibitors disrupting HIF-1α/von Hippel-Lindau interaction through shape-based screening and cascade docking. PeerJ. 2016 Dec 15;4:e2757.