产品说明书
LRE1
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同义名 : | - |
| CAS号 : | 1252362-53-0 | |
| 货号 : | A1176389 | |
| 分子式 : | C12H13ClN4S | |
| 纯度 : | 97% | |
| 分子量 : | 280.776 | |
| MDL号 : | MFCD23148480 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(427.39 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | LRE1 targets the bicarbonate activator binding site, thereby inhibiting soluble adenylyl cyclase (sAC) through a distinctive allosteric mechanism. It hinders sAC-dependent activities within cellular and physiological contexts, paving the way for investigating the therapeutic benefits of sAC inhibition. Administered in a range of 0.5-100 μM for 60 minutes, LRE1 effectively impairs both sperm and mitochondrial functions associated with sAC[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.56mL 0.71mL 0.36mL |
17.81mL 3.56mL 1.78mL |
35.62mL 7.12mL 3.56mL |
| 参考文献 |
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