产品说明书
Thiamine monochloride
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同义名 : | Vitamin B1 |
| CAS号 : | 59-43-8 | |
| 货号 : | A117613 | |
| 分子式 : | C12H17ClN4OS | |
| 纯度 : | 98% | |
| 分子量 : | 300.808 | |
| MDL号 : | MFCD00044586 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 1 mg/mL(3.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(332.44 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Thiamine monochloride (Vitamin B1) is crucial for converting food into cellular energy and supporting normal neuronal activities[1]. Blood thiamine levels in homozygous knockout (KO) and knock-in (KI) mice on a standard diet at 7 weeks are reduced to 0.058±0.051 and 0.126±0.092 μM, respectively, compared to wild type (WT) mice, which show levels of 0.796±0.259 μM. Under a thiamine-restricted diet (0.60 mg/100 g food), the thiamine levels in WT, KO, and KI mice plummet to 0.010±0.009 and 0.010±0.006 μM at 5 and 14 days, respectively, versus 0.609±0.288 μM in WT mice. In brain homogenates of WT mice on a standard diet, thiamine concentrations are 3.81±2.18 nmol/g wet weight, compared to 1.33±0.96 and 2.16±1.55 nmol/g for KO and KI, respectively. For those on a thiamine-restricted diet for 5 and 14 days, thiamine levels in KO and KI mice's brain homogenates drop to 0.95±0.72 and 1.11±0.24 nmol/g, respectively, versus 3.65±1.02 nmol/g in WT mice, just before displaying disease symptoms[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01412580 | - | Completed | - | Tanzania ... 展开 >> MUHAS Dar es Salaam, Tanzania 收起 << | |
| NCT02184325 | Healthy | Phase 2 | Completed | - | - |
| NCT03177161 | Stroke Cerebr... 展开 >>al Infarction Cerebral Hemorrhage Stroke Hemorrhagic Stroke, Ischemic Stroke of Uncertain Pathology 收起 << | Not Applicable | Completed | - | United Kingdom ... 展开 >> Ysbyty Ystrad Fawr Ystrad Mynach, Caerphilly, United Kingdom, CF82 7EP Royal Gwent Hospital Newport, Gwent, United Kingdom, NP20 2UB Nevill Hall Hospital Abergavenny, Monmouthshire, United Kingdom, NP7 7EG Prince Charles Hospital Merthyr Tydfil, United Kingdom, CF47 9DT 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.32mL 0.66mL 0.33mL |
16.62mL 3.32mL 1.66mL |
33.24mL 6.65mL 3.32mL |
| 参考文献 |
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