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Melatonin-d4

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Chemical Structure| 66521-38-8 同义名 : 褪黑素 d4 ;N-Acetyl-5-methoxytryptamine-d4
CAS号 : 66521-38-8
货号 : A1174081
分子式 : C13H16N2O2
纯度 : 98% 98%atom%D
分子量 : 236.303
MDL号 : MFCD03428096
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(444.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Melatonin-d4 is a deuterium-labeled version of melatonin, which is a hormone produced by the pineal gland. Melatonin engages with melatonin receptors and is known for its antioxidative and anti-inflammatory properties[1].[2].[3]. In addition to these roles, melatonin acts as a selective inhibitor of ATF-6 and can induce apoptosis in human hepatoma cells through the downregulation of COX-2[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.23mL

0.85mL

0.42mL

21.16mL

4.23mL

2.12mL

42.32mL

8.46mL

4.23mL
参考文献

[1]Kilic U, et al. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox Biol. 2017 Apr 5;12:657-665

[2]Hu C, et al. Neuroprotective effect of melatonin on soluble Aβ1-42-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway. Neurol Res. 2017 Apr 7:1-1

[3]Rahim I, et al. Melatonin administration to wild-type mice and non-treated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res. 2017 Mar 31

[4]Bu LJ, et al. Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation. World J Gastroenterol. 2017 Feb 14;23(6):986-998.