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Lenalidomide-Br

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Chemical Structure| 2093387-36-9 同义名 : -
CAS号 : 2093387-36-9
货号 : A1173037
分子式 : C13H11BrN2O3
纯度 : 97%
分子量 : 323.142
MDL号 : MFCD32063479
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(27.85 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Lenalidomide-Br, a cereblon (CRBN) ligand analog of Lenalidomide for E3 ubiquitin ligase, facilitates the recruitment of the CRBN protein. It can be linked to a target protein's ligand to construct PROTACs like the PROTAC STAT3 degrader SD-36[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.09mL

0.62mL

0.31mL

15.47mL

3.09mL

1.55mL

30.95mL

6.19mL

3.09mL
参考文献

[1]Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17.

[2]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.