产品说明书

BMS-1166

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Chemical Structure| 1818314-88-3 同义名 : -
CAS号 : 1818314-88-3
货号 : A1168529
分子式 : C36H33ClN2O7
纯度 : 99%+
分子量 : 641.109
MDL号 : MFCD31746874
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(187.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PD-1/PD-L1 interaction

    PD-1/PD-L1 interaction, IC50:1.4 nM
描述 BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces PD-L1 dimerisation and blocks its interaction with PD-1 with an IC50 of 1.4 nM. BMS-1166 antagonises the inhibitory effect of PD-1/PD-L1 immune checkpoints on T-cell activation[1][2].BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in homogenous time-resolved fluorescence binding assay[1].BMS-1166 antagonises the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose-dependently abrogates the inhibitory effect of sPD-L1 on EC stimulation[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.56mL

0.31mL

0.16mL

7.80mL

1.56mL

0.78mL

15.60mL

3.12mL

1.56mL
参考文献

[1]Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867.

[2]Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.