RO-3

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Chemical Structure| 1026582-88-6 同义名 : -
CAS号 : 1026582-88-6
货号 : A1167270
分子式 : C16H22N4O2
纯度 : 98%+
分子量 : 302.372
MDL号 : MFCD12828747
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(396.86 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RO-3 is described as a strong, central nervous system-penetrating, and orally administered antagonist of the P2X3 and P2X2/3 receptors, demonstrating pIC50 values of 5.9 and 7.0 against human P2X3 and P2X2/3 receptors, respectively. This compound is distinguished by its selectivity towards P2X3 and P2X2/3 receptors, showing no significant activity against other P2X receptor types (IC50 >10 μM for P2X1,2,4,5,7)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.07mL

6.61mL

3.31mL
参考文献

[1]Ford AP, et al. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol. 2006;147 Suppl 2(Suppl 2):S132-S143.