SIS17

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Chemical Structure| 2374313-54-7 同义名 : -
CAS号 : 2374313-54-7
货号 : A1166937
分子式 : C21H38N2OS
纯度 : 99%+
分子量 : 366.6
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(286.41 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Histone deacetylases (HDACs) are a class of zinc-dependent amide hydrolases with important biological functions. They catalyze the deacetylation of numerous substrate proteins, including histones, transcription factors, and signaling proteins, and thus regulate various biological processes. SIS17, a HDAC 11 inhibitor with an IC50 value of 0.83 μM, inhibits the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Using a myristoyl-SHMT2 peptide as the substrate, SIS17 could still inhibit HDAC11 with IC50 value of 270 nM. SIS17 increased the fatty acylation level of SHMT2 significantly in MCF7 cells down to 12.5 μM, demonstrating that it is cell permeable and can inhibit HDAC11 in living cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.64mL

2.73mL

1.36mL

27.28mL

5.46mL

2.73mL
参考文献

[1]Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019;14(7):1393-1397