产品说明书

	同义名 :	SRT1720;SIRT-1933;CAY10559;SRT 1720 (hydrochloride);SRT1720 HCl
	CAS号 :	1001645-58-4
	货号 :	A1165814
	分子式 :	C25H23N7OS.xHCl
	纯度 :	99%+
	分子量 :	506.02
	MDL号 :	MFCD18074509
	存储条件：	粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. SRT 1720 is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). In diet-induced obese and diabetic leptin-deficient ob/ob mice, oral administration of 100 mg/kg SRT1720 once daily improves insulin sensitivity, lowers plasma glucose and increases mitochondrial capacity after one week of treatment[1]. SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.98mL 0.40mL 0.20mL	9.88mL 1.98mL 0.99mL	19.76mL 3.95mL 1.98mL

参考文献
[1]Milne JC, Lambert PD, Schenk S, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007;450(7170):712-716. [2]Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R. Are sirtuins viable targets for improving healthspan and lifespan?. Nat Rev Drug Discov. 2012;11(6):443-461.