产品说明书

TCN 213

Print
Chemical Structure| 556803-08-8 同义名 : -
CAS号 : 556803-08-8
货号 : A1164152
分子式 : C18H24N4OS2
纯度 : 95%
分子量 : 376.539
MDL号 : MFCD04788042
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(663.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TCN 213 is a selective, surmountable, glycine-dependent GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, and 40 μM in the presence of glycine at concentrations of 75 nM, 750 nM, and 7,500 nM, respectively.TCN 213 can be used to pharmacologically monitor changes in NMDAR expression in developing cortical neurons[1][2].At a concentration of 30 µM, TCN 213 antagonises NMDA-evoked currents in neurons transfected with the GluN2A subunit[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.28mL

2.66mL

1.33mL

26.56mL

5.31mL

2.66mL
参考文献

[1]McKay, S et al. “Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.” British journal of pharmacology vol. 166,3 (2012): 924-37.

[2]Edman S, et al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep;63(3):441-9.