产品说明书

DMX-5804

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Chemical Structure| 2306178-56-1 同义名 : DMX-5084
CAS号 : 2306178-56-1
货号 : A1155036
分子式 : C21H19N3O3
纯度 : 99%
分子量 : 361.394
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(332.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor with an IC50 value of 3 nM and a pIC50 of 8.55 against human MAP4K4, and weakly against MINK1/MAP4K6 (pIC50, 8.18) and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances the cardiac function in mice. DMX-5804 increases the survival of mouse cardiomyocytes and attenuates ischaemia-reperfusion injury[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.84mL

2.77mL

1.38mL

27.67mL

5.53mL

2.77mL
参考文献

[1]Fiedler LR, et al. MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo. Cell Stem Cell. 2019 Mar 1. pii: S1934-5909(19)30013-X.