产品说明书

NSC-207895

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Chemical Structure| 58131-57-0 同义名 : XI-006;NSC 179940;NSC-207895, NSC207895, NSC 207895, NSC179940, NSC-179940, NSC 179940, XI-006, XI 006, XI006
CAS号 : 58131-57-0
货号 : A1153021
分子式 : C11H13N5O4
纯度 : 99%
分子量 : 279.252
MDL号 : MFCD01660065
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(107.43 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NSC-207895 (XI-006), a DNA damaging agent, serves as an anticancer agent and p53 activator[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.58mL

0.72mL

0.36mL

17.90mL

3.58mL

1.79mL

35.81mL

7.16mL

3.58mL
参考文献

[1]Laura Kapitzky, et al. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451.

[2]Erdenezaya Odkhuu, et al. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B. Immunobiology. 2015 Jan;220(1):136-41.

[3]Luis A Carvajal, et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med. 2018 Apr 11;10(436):eaao3003.