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TLR7/8 agonist 1 2HCl

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Chemical Structure| 1620278-72-9 同义名 : TLR7/8 Agonist 1 (hydrochloride);TLR7/8 agonist 1 dihydrochloride;TLR7/8 agonist-5d
CAS号 : 1620278-72-9
货号 : A1151906
分子式 : C22H27Cl2N5
纯度 : 99%+
分子量 : 432.389
MDL号 : MFCD31657341
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(196.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TLR7/8 agonist 1 2HCl is a TLR7/TLR8 dual antagonist of imidazoquinolines[1][2].TLR7/8 agonist 1 2HCl has significant immunostimulatory activity. TLR7/8 Agonist 1 2HCl is a flexible precursor that can be covalently linked to fluorophores without significant loss of activity. TLR7/8 Agonist 1 2HCl can be directly linked with commercial fluorescein isothiocyanate and TLR7/8 Agonist 1 2HCl can be covalently coupled directly to commercial fluorescein isothiocyanate and rhodamine B isothiocyanate. TLR7/8 Agonist 1 2HClretains TLR7 antagonistic activity with an EC50 of 20 nM[1].TLR7/8 agonist 1 2HCl has agonistic potency against human TLR7/8 with IC50 values of 50 nM and 55 nM, respectively[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.56mL

2.31mL

1.16mL

23.13mL

4.63mL

2.31mL
参考文献

[1]Shukla NM, et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6384-6.

[2]Beesu M, et al. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J Med Chem. 2015 Oct 8;58(19):7833-49.