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PMX-53

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Chemical Structure| 219639-75-5 同义名 : 3D53
CAS号 : 219639-75-5
货号 : A1150801
分子式 : C47H65N11O7
纯度 : 99%
分子量 : 896.088
MDL号 : MFCD07363866
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 190 mg/mL(212.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(2.79 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 PMX 53 is a potent C5a receptor antagonist (IC50 = 20 nM). Also MrgX2 agonist, it stimulates MrgX2-mediated mast cell degranulation, also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.12mL

0.22mL

0.11mL

5.58mL

1.12mL

0.56mL

11.16mL

2.23mL

1.12mL