Oxiracetam

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Chemical Structure| 62613-82-5 同义名 : ISF2522;CGP 21690E;Hydroxypiracetam;Neuractiv
CAS号 : 62613-82-5
货号 : A115017
分子式 : C6H10N2O3
纯度 : 97%
分子量 : 158.155
MDL号 : MFCD00242951
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(158.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(632.29 mM)
动物实验配方：
生物活性
描述 Oxiracetam is a cyclic derivative of γ-aminobutyric acid (GABA) which has been commonly used as nootropic drug to treat cognitive impairments[3]. Rats were administered with propionic acid (250 mg/kg p.o.) for 3 days and immediately on next day treatment were given with oxiracetam (25, 50 mg/kg i.p), zinc (4 mg/kg) as well as oxiracetam (25 mg/kg i.p) in combination with zinc (4 mg/kg p.o). Treatment with oxiracetam alone and in combination with zinc significantly attenuated behavioral, biochemical, inflammatory cytokines and restored neurotransmitters level[4]. ORC (oxiracetam) suppressed the activation of BV2 cells, decreased the production of Aβ-induced inflammatory molecules and NO in BV2 cells, and protected HT22 cells against indirect toxicity mediated by Aβ-treated BV2 cell-conditioned medium. Thus, ORC may exert a protective role in AD through attenuating the damage caused by inflammation and oxidative stress[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.32mL

1.26mL

0.63mL

31.61mL

6.32mL

3.16mL

63.23mL

12.65mL

6.32mL
参考文献

[1]Spignoli G, Pepeu G. Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine. Pharmacol Biochem Behav. 1987 Jul;27(3):491-5.

[2]Sansone M, Castellano C, Ammassari-Teule M. Improvement of avoidance acquisition by the nootropic drug oxiracetam in mice. Arch Int Pharmacodyn Ther. 1985 May;275(1):86-92.

[3]Li W, Liu H, Jiang H, Wang C, Guo Y, Sun Y, Zhao X, Xiong X, Zhang X, Zhang K, Nie Z, Pu X. (S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats. Sci Rep. 2017 Aug 30;7(1):10052

[4]Paudel R, Raj K, Gupta YK, Singh S. Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats. Neurotox Res. 2020 Apr;37(4):815-826

[5]Zhang H, Jia L, Jia J. Oxiracetam Offers Neuroprotection by Reducing Amyloid β-Induced Microglial Activation and Inflammation in Alzheimer's Disease. Front Neurol. 2020 Jul 17;11:623