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Antineoplaston A10

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Chemical Structure| 91531-30-5 同义名 : -
CAS号 : 91531-30-5
货号 : A1149313
分子式 : C13H14N2O3
纯度 : 99%+
分子量 : 246.262
MDL号 : MFCD26961095
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1015.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Antineoplaston A10 intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis. Antineoplaston A10 also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. It is originally isolate from human urine but is now synthetically derived. It has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver cancer, and Kidney Cancer, among others. The experiment among patient with HBSG suggest to use A10 9.22g/kg/d with AS2-1 0.31g/kg/d for over 5 months, and the overall survival at 2 and 5 years was 39% and 22%[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.06mL

0.81mL

0.41mL

20.30mL

4.06mL

2.03mL

40.61mL

8.12mL

4.06mL
参考文献

[2]Burzynski, S. R. et al. Targeted Therapy With Antineoplastons A10 and AS2-1 of high-grade, recurrent, and progressive brainstem glioma. Sage journals. 2006.