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cFMS Receptor Inhibitor II

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Chemical Structure| 959860-85-6 同义名 : -
CAS号 : 959860-85-6
货号 : A1149117
分子式 : C23H20N4O
纯度 : 99%+
分子量 : 368.431
MDL号 : MFCD28138115
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(230.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Macrophage colony stimulating factor (MCSF) is a hematopoietic growth factor that plays an important role in inflammation and angiogenesis. cFMS, the cellular receptor for MCSF, is required for MCSF activation. cFMS receptor inhibitor II exhibited high potency and selectivity against c-FMS with an IC50 value of 80nM. It also showed an IC50 value of 0.1μM against the cell line expressing MCSF. In non-MCSF expressing cell line (NSO), the IC50 value for cFMS receptor inhibitor II is > 50μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.57mL

2.71mL

1.36mL

27.14mL

5.43mL

2.71mL
参考文献

[1]Smalley TL Jr, Chamberlain SD, Mills WY, Musso DL, Randhawa SA, Ray JA, Samano V, Frick L. Synthesis of novel anilinoquinolines as c-fms inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6257-60.