Thalidomide-PEG2-C2-NH2 HCl

产品说明书

Print
Chemical Structure| 2245697-87-2 同义名 : -
CAS号 : 2245697-87-2
货号 : A1148614
分子式 : C19H25ClN4O6
纯度 : 95%
分子量 : 440.878
MDL号 : MFCD31689260
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized conjugate comprising an E3 ligase ligand-linker that integrates the cereblon ligand based on Thalidomide and a 2-unit PEG linker, utilized in PROTAC technology[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.34mL

2.27mL

1.13mL

22.68mL

4.54mL

2.27mL
参考文献

[1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.