产品说明书

CYM50358

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Chemical Structure| 1314212-39-9 同义名 : -
CAS号 : 1314212-39-9
货号 : A1148456
分子式 : C20H18Cl2N2O2
纯度 : 99%+
分子量 : 389.275
MDL号 : MFCD28386025
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(308.27 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sphingosine 1-phosphate (S1P) is a signaling lipid which is an important regulator in inflammation, angiogenesis, vascular permeability, brain and cardiac development and cancer growth and metastasis[1]. CYM-50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25nM. CYM50358 shows less potent inhibition of S1PR1 (IC50=6.4 μM)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.84mL

2.57mL

1.28mL

25.69mL

5.14mL

2.57mL
参考文献

[1]Bryan AM, Del Poeta M. Sphingosine-1-phosphate receptors and innate immunity. Cell Microbiol. 2018 May;20(5):e12836.

[2]Guerrero M, Urbano M, Velaparthi S, et al. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett. 2011;21(12):3632-3636.