PROTAC BET degrader-2
产品说明书
 |
同义名 : | - |
| CAS号 : | 2093388-33-9 | |
| 货号 : | A1148016 | |
| 分子式 : | C41H42N10O6 | |
| 纯度 : | 98% | |
| 分子量 : | 770.84 | |
| MDL号 : | MFCD31807624 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(64.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | PROTAC BET degrader-25 is PROTAC targeting on BET proteins, consist of a BET inhibitor HJB97 as the warhead ligand and a Lenalidomide analogue as the CRBN ligand. PROTAC BET degrader-25 at concentration of 10, 30 and 100nM led a dose-dependent degradation of BRD2, 3 and 4 at different levels post 3-hour treatment in RS4;11 cells. PROTAC BET degrader-25 exhibited potency against MOLM-13 and RS4;11 with IC50 values of 9.6nM and 72.3nM, respectively[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.30mL 0.26mL 0.13mL |
6.49mL 1.30mL 0.65mL |
12.97mL 2.59mL 1.30mL |
| 参考文献 |
|---|