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Ginsenoside Rd

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Chemical Structure| 52705-93-8 同义名 : 人参皂甙 Rd ;Gypenoside VIII;Panaxoside Rd;Sanchinoside Rd
CAS号 : 52705-93-8
货号 : A114690
分子式 : C48H82O18
纯度 : 98%
分子量 : 947.154
MDL号 : MFCD00210508
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(110.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Calcium Channel
描述 Ginsenoside Rd (GSRd), one of the main active ingredients in traditional Chinese herbal Panax ginseng, have therapeutic effects on ischemic stroke. in vitro, GSRd administration reduced mtDNA and nDNA damages and reduced cell apoptosis and the expression of cleaved caspase-3 in rats at 7 days after middle cerebral artery occlusion (MCAO)[3]. Moreover, pretreatment with Rd at 1 or 10 μM in the medium partly reversed the Ca2+ induced mitochondrial swelling. in vivo, pretreatment with Rd (10 and 50 mg/kg) protected spinal cord mitochondria against Ca2+ induced mitochondrial membrane potential dissipation and cytochrome release[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.06mL

0.21mL

0.11mL

5.28mL

1.06mL

0.53mL

10.56mL

2.11mL

1.06mL
参考文献

[1]Liu XY, Zhou XY, et al. Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway. Acta Pharmacol Sin. 2015 Apr;36(4):421-8.

[2]Wang B, Zhu Q, et al. Ginsenoside Rd inhibits apoptosis following spinal cord ischemia/reperfusion injury. Neural Regen Res. 2014 Sep 15;9(18):1678-87.

[3] Yang LX, Zhang X, Zhao G. Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia. Chin Med J (Engl). 2016;129(16):1955-1962.

[4]Zhou JS, Wang JF, He BR, et al. Ginsenoside Rd attenuates mitochondrial permeability transition and cytochrome C release in isolated spinal cord mitochondria: involvement of kinase-mediated pathways. Int J Mol Sci. 2014;15(6):9859-9877. Published 2014 Jun 3.