VH032-linker 5

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Chemical Structure| 2172819-74-6 同义名 : (S,R,S)-AHPC-C4-COOH; VH032-C4-COOH; (S, R, S)-AHPC-pentanoic-acid
CAS号 : 2172819-74-6
货号 : A1146496
分子式 : C28H38N4O6S
纯度 : 95%
分子量 : 558.69
MDL号 : MFCD32693310
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 (S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) is a synthesized conjugate consisting of an E3 ligase ligand linked to a linker molecule. This conjugate incorporates the (S,R,S)-AHPC-based VHL ligand, and the linker is utilized for EED-targeted PROTAC applications[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.79mL

0.36mL

0.18mL

8.95mL

1.79mL

0.90mL

17.90mL

3.58mL

1.79mL
参考文献

[1]Liu Jing, et al. Preparation of pyrazolopyridines and related heterocycles as CBP and p300 degradation bivalent compds for treatment of diseases. World Intellectual Property Organization, WO2020173440 A1 2020-09-03