产品说明书

Diprotin A

Print
Chemical Structure| 90614-48-5 同义名 : Ile-Pro-Ile
CAS号 : 90614-48-5
货号 : A114611
分子式 : C17H31N3O4
纯度 : 98%
分子量 : 341.446
MDL号 : MFCD00038707
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(307.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(292.87 mM)
动物实验配方：
生物活性
描述 Diprotin A is an inhibitor of DPP-IV. Diprotin A induces phosphorylation of Src[Tyr 416] and VE-cadherin[Tyr731] and disrupts endothelial cell-cell junctions in human endothelial cells under normoxic and H/R conditions after treatment with a CXCR4 receptor blocker or Src inhibitor at a concentration of 100 μM for 30 min, whereas CXCR4 (SDF-1α receptor) blockers or Src inhibitors attenuate this effect[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.64mL

2.93mL

1.46mL

29.29mL

5.86mL

2.93mL
参考文献

[1]Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.