Compound E

产品说明书

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Chemical Structure| 209986-17-4 同义名 : γ-Secretase-IN-1;γ-Secretase Inhibitor XXI;ɣ-secretase inhibitor XXI;GSI-XXI
CAS号 : 209986-17-4
货号 : A1145654
分子式 : C27H24F2N4O3
纯度 : 99%+
分子量 : 490.501
MDL号 : MFCD04974531
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(214.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Compound E inhibits the growth of T47D and MCF-7 cell lines by less than 50% at a 50 μM concentration[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.19mL

2.04mL

1.02mL

20.39mL

4.08mL

2.04mL
参考文献

[1]Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402.