Mulberrin

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Chemical Structure| 62949-79-5 同义名 : Kuwanon C
CAS号 : 62949-79-5
货号 : A114413
分子式 : C25H26O6
纯度 : 98%
分子量 : 422.47
MDL号 : MFCD20274692
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(248.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Abnormal neuroinflammation and oxidative stress has been shown to cause neuronal loss in the progressive neurodegenerative Parkinson's disease (PD). Mulberrin is the key component of Ramulus Mori that has various biological activities. In an in vitro PD model using the mouse microglial BV2 cells treated with LPS, mulberrin not only reduced IL-6, IL-10 and TNF-α expression levels, but also suppressed NO contents, iNOS mRNA expression and ROS contents, suggesting that LPS induced inflammatory response and oxidative stress were partially suppressed by mulberrin treatment. Rota-rod test was applied to investigate the roles of mulberrin on MPTP-induced behavioral impairment. Treatment of mulberrin together with MPTP restored rats’ residence duration on the rota-rod in a dose dependent manner. While rats treated with a higher dose of mulberrin (30 mg/kg) remained significantly longer on the rota-rod compared to rats treated with MPTP alone. These results indicate that mulberrin treatment alleviates MPTP mediated disruption in balance and motor coordination. Furthermore, mulberrin suppresses MPTP induced inflammatory response and oxidative stress [3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.84mL

2.37mL

1.18mL

23.67mL

4.73mL

2.37mL
参考文献

[1]Wen F, Shi M, et al. Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharm Biol. 2016;54(2):293-302.

[2]Syahdi RR, Mun'im A, et al. Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor. Bioinformation. 2012;8(24):1206-10.

[3]Cao W, Dong Y, Zhao W, Lu X, Sun L. Mulberrin attenuates 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced Parkinson's disease by promoting Wnt/β-catenin signaling pathway. J Chem Neuroanat. 2019 Jul;98:63-70. doi: 10.1016/j.jchemneu.2019.04.003. Epub 2019 Apr 9. PMID: 30978489.