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CZC-8004

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Chemical Structure| 916603-07-1 同义名 : CZC-00008004;Dianilinopyrimidine-01
CAS号 : 916603-07-1
货号 : A114366
分子式 : C17H16FN5
纯度 : 96%+
分子量 : 309.341
MDL号 : MFCD16251195
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 80 mg/mL(258.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders, including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL. ABL therefore represents a crucial target for new therapeutic strategies[3]. CZC-8004 is a pan-kinase inhibitor, with low micromolar IC50 values for tyrosine kinase including ABL kinase. A 50% bead loading gave the highest level of PK (protein kinase) identification for CZC-8004, extracting 55 PKs from a single cell lysate. The CZC-8004 beads extracted 61 and 64 PKs with 55 PKs common across the two bead batches examined[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.16mL

3.23mL

1.62mL

32.33mL

6.47mL

3.23mL
参考文献

[1]CZC-8004 is a pan-kinase inhibitor, with low micromolar IC50 values for tyrosine kinase.

[2]Bantscheff M, et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol. 2007 Sep;25(9):1035-44.

[3]Cilloni D, Saglio G. Molecular pathways: BCR-ABL. Clin Cancer Res. 2012 Feb 15;18(4):930-7.

[4]Deane FM, Lin AJS, Hains PG, Pilgrim SL, Robinson PJ, McCluskey A. FD5180, a Novel Protein Kinase Affinity Probe, and the Effect of Bead Loading on Protein Kinase Identification. ACS Omega. 2017 Jul 31;2(7):3828-3838.