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CC-671

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Chemical Structure| 1618658-88-0 同义名 : -
CAS号 : 1618658-88-0
货号 : A1142874
分子式 : C28H28N6O4
纯度 : 99%+
分子量 : 512.56
MDL号 : MFCD31619262
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(117.06 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CC-671 is a TTK protein kinase/CDC2-like kinase (CLK2) dual inhibitor with IC50s of 0.005 and 0.006 μM for TTK and CLK2, respectively. When 3 μM CC-671 was used to treat HCT-116 cell lysates for 1 hour, it was found that only four kinases had a binding rate of 75% or more to the cells, including CLK2, CAMKK2, PIP4K22 and JNK[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.20mL

9.75mL

1.95mL

0.98mL

19.51mL

3.90mL

1.95mL
参考文献

[1]Riggs JR, et al. The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatmentof Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J Med Chem. 2017 Nov 9;60(21):8989-9002.