产品说明书

Flumazenil acid

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Chemical Structure| 84378-44-9 同义名 : Ro 15-3890
CAS号 : 84378-44-9
货号 : A112716
分子式 : C13H10FN3O3
纯度 : 99%+
分子量 : 275.235
MDL号 : MFCD08061420
存储条件:

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(381.49 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Ro 15-3890 is the metabolite from the biotransformation of the imidazobenzodiazepine antagonist flumazenil. Flumazenil is GABAa receptor antagonist.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.63mL

0.73mL

0.36mL

18.17mL

3.63mL

1.82mL

36.33mL

7.27mL

3.63mL

参考文献

[1]Isolation and Pharmacological Characterization of Microsomal Human Liver Flumazenil Carboxylesterase

[2]Mograbi KM, de Castro AC, et al. Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice. Physiol Rep. 2017 Mar;5(6). pii: e13081.