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Altretamine

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Chemical Structure| 645-05-6 同义名 : ENT-50852;RB-1515;HMM;2,4,6-Tris(dimethylamino)-1,3,5-triazine;NSC13875;Hexamethylmelamine;WR-95704
CAS号 : 645-05-6
货号 : A112657
分子式 : C9H18N6
纯度 : 97%
分子量 : 210.279
MDL号 : MFCD00549245
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 7 mg/mL(33.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 5% DMSO+5% Tween80+40% PEG300+water 1 mg/mL clear

PO 0.5% CMC-Na 33 mg/mL suspension

生物活性
描述 Altretamine is an antineoplastic agent approved for the treatment of ovarian cancer. It displays cytotoxic activity in a human ovarian carcinoma cell line at a concentration of 10μg/mL[3]. In a mouse model of M5076 reticulum cell sarcoma, treatment with altretamine at a dosage of 150mg/kg resulted in 70% inhibition of tumor volume[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.76mL

0.95mL

0.48mL

23.78mL

4.76mL

2.38mL

47.56mL

9.51mL

4.76mL
参考文献

[1]Chan JK, Loizzi V, et al. Oral altretamine used as salvage therapy in recurrent ovarian cancer. Gynecol Oncol. 2004 Jan;92(1):368-71.

[2]Malik IA. Altretamine is an effective palliative therapy of patients with recurrent epithelial ovarian cancer. Jpn J Clin Oncol. 2001 Feb;31(2):69-73.

[3]D'Incalci M, Erba E, Balconi G, Morasca L, Garattini S. Time dependence of the in vitro cytotoxicity of hexamethylmelamine and its metabolites. Br J Cancer. 1980 Apr;41(4):630-5.

[4]Triazines and related products. Part 26. Synthesis and chemistry of bicyclic analogues of the antitumour drug 2,4,6-tris(dimethylamino)-1,3,5-triazine (hexamethylmelamine). J. Chem. Soc., Perkin Trans. 1, 1984, 993-998.