产品说明书

U-104

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Chemical Structure| 178606-66-1 同义名 : -
CAS号 : 178606-66-1
货号 : A112487
分子式 : C13H12FN3O3S
纯度 : 98%
分子量 : 309.316
MDL号 : MFCD00159265
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(339.46 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

30% PEG400+0.5% Tween80+5% propylene glycol+water 30 mg/mL suspension

生物活性
靶点

  • Carbonic Anhydrase IX

    CAIX, Ki:45.1 nM

  • Carbonic Anhydrase XII

    CAXII, Ki:4.5 nM
描述 U-104 (SLC-0111) is a highly potent inhibitor of carbonic anhydrase (CA) targeting CA IX and CA XII, with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 exhibits notable efficacy in delaying tumor growth in mouse models[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.16mL

3.23mL

1.62mL

32.33mL

6.47mL

3.23mL
参考文献

[1]Lou Y, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71(9):3364-76.

[2]Lock FE, et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 2013 Oct 31;32(44):5210-9.

[3]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.