产品说明书

BLT-1

Print
Chemical Structure| 321673-30-7 同义名 : Block lipid transport-1
CAS号 : 321673-30-7
货号 : A1121395
分子式 : C12H23N3S
纯度 : 98%+
分子量 : 241.396
MDL号 : MFCD00571007
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(165.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The high-density lipoprotein (HDL) receptor, scavenger receptor, class B, type I (SR-BI), plays an important role in controlling the structure and metabolism of HDL. BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor that inhibits the transfer of lipids between HDL and cells mediated by SR-BI. In ldlA[mSR-BI] cells, BLT-1 had IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake[2]. BLT-1 inhibited SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1-containing liposomes in cells and liposomes with IC50s of 0.057 and 0.098 µM, respectively[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.14mL

0.83mL

0.41mL

20.71mL

4.14mL

2.07mL

41.43mL

8.29mL

4.14mL
参考文献

[1]Wang W, Yan Z, Hu J, Shen WJ, Azhar S, Kraemer FB. Scavenger receptor class B, type 1 facilitates cellular fatty acid uptake. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865(2):158554.

[2]Nieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7.

[3]Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72.