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Paris saponin VII

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Chemical Structure| 68124-04-9 同义名 : 重楼皂甙Ⅶ ;Chonglou Saponin VII;Dioscinin;Polyphyllin-VII
CAS号 : 68124-04-9
货号 : A111232
分子式 : C51H82O21
纯度 : 98%
分子量 : 1031.184
MDL号 : MFCD20260362
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(101.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chonglou Saponin VII (Paris saponin VII, PSVII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. PSVII (Paris saponin VII) could inhibit the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. PSVII significantly suppressed cell proliferation by cell cycle arrest in the G0/G1 phase. Moreover, PSVII could attenuate mitochondrial membrane potential, increase the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decrease the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. PSVII induced a robust autophagy in K562/ADR cells[2]. The half maximal inhibitory concentration (IC50) value of PS VII for the growth inhibition of Hela cells was 2.62 ± 0.11 μM[3]. Treatment with PSVII influenced cell viability of MCF-7/ADR cells, as well as sensitized MCF-7/ADR cells to the cytotoxic effects of adriamycin. Moreover, PSVII significantly downregulated MDR1 (multidrug-resistant) expression in MCF-7/ADR cells. Intravenous administration of PSVII significantly enhanced anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.97mL

0.19mL

0.10mL

4.85mL

0.97mL

0.48mL

9.70mL

1.94mL

0.97mL
参考文献

[1]Yang R, Qi J, et al. [Effects of Paris polyphylla saponin VII plus silica nano composite on ovarian cancer drug resistance in vitro] . Zhonghua Yi Xue Za Zhi. 2015 Jun 16;95(23):1859-61. Chinese.

[2]Yan T, Hu G, Wang A, Sun X, Yu X, Jia J. Paris saponin VII induces cell cycle arrest and apoptosis by regulating Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells. Phytother Res. 2018 May;32(5):898-907

[3]Zhang W, Zhang D, Ma X, Liu Z, Li F, Wu D. Paris saponin VII suppressed the growth of human cervical cancer Hela cells. Eur J Med Res. 2014 Aug 15;19(1):41

[4]Li Y, Sun Y, Tang T, Niu Y, Li X, Xie M, Jin H, Mei Q. Paris saponin VII reverses chemoresistance in breast MCF-7/ADR cells. J Ethnopharmacol. 2019 Mar 25;232:47-54