4-Butylresorcinol
产品说明书
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同义名 : | 4-正丁基间苯二酚 ;Butylresorcinol;Rucinol;4-n-Butylresorcinol |
| CAS号 : | 18979-61-8 | |
| 货号 : | A110872 | |
| 分子式 : | C10H14O2 | |
| 纯度 : | 98% | |
| 分子量 : | 166.22 | |
| MDL号 : | MFCD01684800 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(631.69 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | 4-Butylresorcinol is a phenol derivative which can inhibit tyrosinase with IC50 of 11.27 μM[1]. 4-Butylresorcinol (4-n-butylresorcinol) significantly inhibits melanin synthesis in a concentration-dependent manner. In addition, it was also found to inhibit the activity of tyrosinase, the rate-limiting melanogenic enzyme. 4-Butylresorcinol does not induce ERK, Akt activation, or MITF degradation, and has no effect on cAMP response element binding protein (CREB) phosphorylation, which stimulates MITF expression. 4-Butylresorcinol strongly reduces tyrosinase activity in a cell-free system. 4-n-butylresorcinol strongly reduced tyrosinase activity in a cell-free system. Moreover, 4-n-butylresorcinol showed an additive effect in combination with hinokitiol, which reduces MITF (microphthalmia-associated transcription factor) expression[2]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.02mL 1.20mL 0.60mL |
30.08mL 6.02mL 3.01mL |
60.16mL 12.03mL 6.02mL |
| 参考文献 |
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