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7ACC2

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Chemical Structure| 1472624-85-3 同义名 : -
CAS号 : 1472624-85-3
货号 : A110822
分子式 : C18H15NO4
纯度 : 99%+
分子量 : 309.316
MDL号 : MFCD28167835
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(161.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 7ACC2, a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for [14C]-lactate influx inhibition, also serves as a strong inhibitor of mitochondrial pyruvate transport. 7ACC2 is identified as an anticancer agent by impeding lactate flux[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.16mL

3.23mL

1.62mL

32.33mL

6.47mL

3.23mL
参考文献

[1]Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.

[2]Cyril Corbet, et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018 Mar 23;9(1):1208.