GKT136901
产品说明书
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同义名 : | NOX Inhibitor IV |
| CAS号 : | 955272-06-7 | |
| 货号 : | A110729 | |
| 分子式 : | C19H15ClN4O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 366.801 | |
| MDL号 : | MFCD09961532 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(95.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | GKT136901 is a potent, selective and orally active inhibitor of NOX1/4, with Ki values of 160 and 165 nM, respectively. It also acts as a selective direct scavenger of peroxynitrite. GKT136901 is applicable in research for diabetic nephropathy, stroke, and neurodegenerative diseases. Additionally, it possesses anti-inflammatory properties[1][2][3]. Treating cells with GKT136901 at a concentration of 10 μM for 30 minutes significantly attenuates the increase in O2- production and H2O2 generation induced by high D-glucose in MPT cells. It also eliminates the effect of high D-glucose on the activation of p38MAP kinase in MPT cells[4]. A 2-hour treatment of cells with GKT136901 at a concentration of 10 μM can alleviate METH-induced oxidative stress in HBMEC and protect against METH-induced blood-brain barrier dysfunction in HBMEC[5]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.73mL 0.55mL 0.27mL |
13.63mL 2.73mL 1.36mL |
27.26mL 5.45mL 2.73mL |
| 参考文献 |
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