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Octenidine 2HCl

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Chemical Structure| 70775-75-6 同义名 : 奥替尼啶双盐酸盐 ;Octenidine (hydrochloride);Octenidine Dihydrochloride;WIN 41,464-2
CAS号 : 70775-75-6
货号 : A110333
分子式 : C36H64Cl2N4
纯度 : 98%
分子量 : 623.826
MDL号 : MFCD01938808
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(6.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(48.09 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Octenidine binds to negatively charged surfaces like bacterial cell envelopes and eukaryotic cell membranes probably inducing membrane disruption. Its main binding partners are salts of fatty acids glycerol phosphates, found in the cell membranes of mammalian and bacterial cells. Due to this strong and unspecific interaction with bacterial walls it has a broad antimicrobial spectrum against a variety of Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), skin microflora and fungi.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02169167 Diabetes Mellitus ... 展开 >> Diabetes Complications Diabetic Neuropathies Wound Infection 收起 << Not Applicable Completed - Poland ... 展开 >> Diabetic Foot Clinic Regional Diabetic Centre, Department of Hypertension and Diabetology Gdańsk, Poland, 80-952 收起 <<
NCT03224299 Preoperative Skin Preparation Phase 2 Completed - United States, Montana ... 展开 >> BioScience Laboratories Bozeman, Montana, United States, 59718 BioScience Laboratories Butte, Montana, United States, 59701 收起 <<
NCT00515151 Catheterization, Central Venou... 展开 >>s Catheter-Associated Infections Bacterial Infections Bacteremia 收起 << Phase 4 Completed - Germany ... 展开 >> Institute of Environmental Medicine and Hospital Epidemiology University Medical Center Freiburg Freiburg, Germany Switzerland Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel Basel, Switzerland 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.02mL

1.60mL

0.80mL

16.03mL

3.21mL

1.60mL