Doripenem Monohydrate

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Chemical Structure| 364622-82-2 同义名 : 多利培南一水合物 ;Doripenem hydrate;S 4661 monohydrate;S-4661
CAS号 : 364622-82-2
货号 : A110224
分子式 : C15H26N4O7S2
纯度 : 98%
分子量 : 438.519
MDL号 : MFCD09749887
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(114.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(22.8 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Doripenem (Hydrate) is a new member of the carbapenem class of beta-lactam antibiotics with broad-spectrum coverage of Gram-positive, Gram-negative and anaerobic pathogens similar to imipenem and, especially, meropenem. Doripenem has a broad spectrum of activity against many common hospital pathogens, including P. aeruginosa and Burkholderia cepacia[3]. Doripenem has been approved for use in treatment of complicated intra-abdominal infection and complicated urinary tract infection. In vitro, doripenem lacks the propensity to cause seizures, and a low risk of seizures has been demonstrated in clinical studies[4]. In addition, the synergistic use of doripenem and cefotaxime plays a significant role in inhibiting the efficiency of CTX-M-15 type β-lactamase[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.40mL

2.28mL

1.14mL

22.80mL

4.56mL

2.28mL
参考文献

[1]Jones RN, Huynh HK, Biedenbach DJ. Activities of doripenem (S-4661) against drug-resistant clinical pathogens. Antimicrob Agents Chemother. 2004 Aug;48(8):3136-40.

[2]Jones RN, Huynh HK, Biedenbach DJ, Fritsche TR, Sader HS. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54.

[3]Anderson DL. Doripenem. Drugs Today (Barc). 2006;42(6):399‐404.

[4]Paterson DL, Depestel DD. Doripenem. Clin Infect Dis. 2009;49(2):291‐298.

[5]Fukui S, Iemura Y, Matsumura Y, Kagebayashi Y, Samma S. Hinyokika Kiyo. 2019;65(1):23‐27.