产品说明书
ABC294640
 |
同义名 : | Opaganib |
| CAS号 : | 915385-81-8 | |
| 货号 : | A110039 | |
| 分子式 : | C23H25ClN2O | |
| 纯度 : | 99%+ | |
| 分子量 : | 380.91 | |
| MDL号 : | MFCD22666355 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
2% DMSO+30% PEG 300+5% Tween 80+water 5 mg/mL |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sphingosine is an intermediate of sphingolipids that can be rapidly phosphorylated by sphingosine kinase (SK1 and SK2) to produce sphingosine 1-phosphate, which is a mitogenic compound. ABC294640 is a selective inhibitor of SK2 with a Ki value of 9.8 μM. ABC294640 dose-dependently inhibited recombinant human SK2 with an IC50 value of 60μM, while the activity of SK1 was not affected by ABC294640 at the concentration up to 100μM. In MDA-MB-231 cells, ABC294640 decreased [3H]S1P formation in a dose-dependent manner with an IC50 value of 26μM. ABC294640 also inhibited the proliferation of human tumor cell lines (1025LU, A-498, Caco-2, HT-29, DU145, SK-OV-3) with IC50 values ranging from 10.5-48.1μM[2]. In a mouse model of tri-nitrobenzene sulfonic acid (TNBS)-induced colitis, oral administration of ABC294640 (50mg/kg, twice daily) decreased TNBS-induced increase in mucosal myeloperoxidase activity by 60%. The histological analysis on colon sections revealed that the inflammation and damage caused by TNBS was reduced or negated by ABC294640 treatment[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.63mL 0.53mL 0.26mL |
13.13mL 2.63mL 1.31mL |
26.25mL 5.25mL 2.63mL |
| 参考文献 |
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