产品说明书
Nα,Nα-Bis(carboxymethyl)-L-lysine
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同义名 : | - |
| CAS号 : | 113231-05-3 | |
| 货号 : | A109900 | |
| 分子式 : | C10H18N2O6 | |
| 纯度 : | 96%+ | |
| 分子量 : | 262.26 | |
| MDL号 : | MFCD00237437 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 1.5 mg/mL(5.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nα,Nα-Bis(carboxymethyl)-L-lysine serves as a competitive antagonist for the bitter taste receptor 4, exhibiting an IC50 of 59 nM. It is applicable in studies related to bitter taste receptors[1][2][3]. At a concentration of 59 nM, Nα,Nα-Bis(carboxymethyl)-L-lysine reduces the basal activity of the H214A mutant of T2R4 by 40%[1]. With a 60 nM concentration for 15 minutes, Nα,Nα-Bis(carboxymethyl)-L-lysine prevents the quinine-induced decrease in the basal activation state of Rac1 in HEK293T cells expressing T2R4 and Ga16/44, but it does not affect HEK293T control cells[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.81mL 0.76mL 0.38mL |
19.07mL 3.81mL 1.91mL |
38.13mL 7.63mL 3.81mL |
| 参考文献 |
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