产品说明书

Ethionamide

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Chemical Structure| 536-33-4 同义名 : 乙硫异酰胺 ;2-Ethylthioisonicotinamide;NSC 255115;Bayer 5312
CAS号 : 536-33-4
货号 : A109412
分子式 : C8H10N2S
纯度 : 98%
分子量 : 166.243
MDL号 : MFCD00057361
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 250 mg/mL(1503.82 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Ethionamide is an antibiotic used in the treatment of tuberculosis.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02099240 Osteomyelitis Early Phase 1 Recruiting September 2019 United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD 收起 <<
NCT02365623 Tuberculosis, Multidrug-Resist... 展开 >>ant 收起 << Phase 2 Active, not recruiting September 12, 2020 Japan ... 展开 >> Kiyose, Japan Sakai, Japan 收起 <<
NCT00000796 HIV Infections ... 展开 >> Tuberculosis 收起 << Not Applicable Completed - United States, Illinois ... 展开 >> Cook County Hosp Chicago, Illinois, United States, 60612 United States, Michigan Henry Ford Hosp Detroit, Michigan, United States, 48202 United States, New York Bronx Lebanon Hosp Ctr Bronx, New York, United States, 10456 Bronx Municipal Hosp Ctr/Jacobi Med Ctr Bronx, New York, United States, 10461 Comprehensive Health Care Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10461 Montefiore Drug Treatment Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10461 Montefiore Family Health Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10461 Samaritan Village Inc / Bronx Municipal Hosp Bronx, New York, United States, 10461 Jack Weiler Hosp / Bronx Municipal Hosp Bronx, New York, United States, 10465 Montefiore Med Ctr / Bronx Municipal Hosp Bronx, New York, United States, 10467 North Central Bronx Hosp / Bronx Municipal Hosp Bronx, New York, United States, 10467 Interfaith Med Ctr Brooklyn, New York, United States, 112032098 SUNY / Health Sciences Ctr at Brooklyn Brooklyn, New York, United States, 112032098 Beth Israel Med Ctr New York, New York, United States, 10003 Clinical Directors Network of Region II New York, New York, United States, 10011 Bellevue Hosp / New York Univ Med Ctr New York, New York, United States, 10016 Saint Clare's Hosp and Health Ctr New York, New York, United States, 10019 Cornell Univ Med Ctr New York, New York, United States, 10021 Mount Sinai Med Ctr New York, New York, United States, 10029 Columbia Presbyterian Med Ctr New York, New York, United States, 100323784 Harlem AIDS Treatment Group / Harlem Hosp Ctr New York, New York, United States, 10037 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.02mL

1.20mL

0.60mL

30.08mL

6.02mL

3.01mL

60.15mL

12.03mL

6.02mL

参考文献

[1]Ang MLT, Zainul Rahim SZ, et al. EthA/R-Independent Killing of Mycobacterium tuberculosis by Ethionamide. Front Microbiol. 2017 Apr 25;8:710.

[2]Clarke GB, O'Hea AJ. Chronic pulmonary tuberculosis treatment with ethionamide combined with cycloserine or oxytetracycline. Br Med J. 1961 Mar 4;1(5226):636-8.